safety▌

Toxicity assessment: identify the chemical, check known hazards (GHS, IARC), then look for ADMET predictions. Dose makes the poison — always consider exposure level, as a compound that is toxic at high doses may be safe at relevant exposures. Distinguish between acute toxicity (LD50, GHS category) and chronic hazards (carcinogenicity, endocrine disruption) — they require different risk management approaches. Computational predictions (ADMETAI) are T3 evidence and must be anchored by experimental

End-to-end type-safe APIs for TypeScript with zero code generation. \n \n Shares TypeScript types between client and server automatically—no codegen required, with full type inference across queries, mutations, and subscriptions \n Integrates seamlessly with React Query for caching, optimistic updates, and infinite queries; supports Next.js App Router, Server Components, and WebSocket subscriptions \n Validates all inputs with Zod schemas; includes middleware for authentication, logging, and rat

Static type checking with annotations, generics, protocols, and strict mode enforcement. \n \n Covers type annotations, generics with TypeVars, structural protocols, and type narrowing patterns for catching errors at analysis time \n Includes modern syntax (Python 3.10+ union types), bounded type variables, and generic repository patterns for type-safe APIs \n Provides configuration guidance for mypy strict mode and incremental adoption strategies for existing codebases \n Demonstrates 10 fundam